2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-127162
    Prostaglandin K1
    Prostaglandin K1 (compound 46) is a structurally modified analog of prostacyclin (prostanoid) with an EC50 of 2800 nM for EP1 and a Ki of 2800 nM.
    Prostaglandin K1
  • HY-124209
    9-keto Fluprostenol
    9-keto Fluprostenol is an analog of prostaglandin E2 (PGE2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. It is anticipated that this analog will have strong affinity for EP receptors and act as a PGE2 agonist.
    9-keto Fluprostenol
  • HY-114822
    Prostaglandin A3
    Prostaglandin A3 is a non-enzymatic dehydration product of prostaglandin E3 (PGE3). Prostaglandin A3 showed good affinity for canine EP2 and EP4 receptors with IC50 values of 120 and 20 nM, respectively. The Ki value of Prostaglandin A3 for human PPARγ was 188 μM.
    Prostaglandin A3
  • HY-118624
    Fluprostenol methyl ester
    Fluprostenol methyl ester is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals.
    Fluprostenol methyl ester
  • HY-16635R
    Setipiprant (Standard)
    		Antagonist
    Setipiprant (Standard) is the analytical standard of Setipiprant. This product is intended for research and analytical applications. Setipiprant (ACT-129968) is an orally active and selective CRTH2 antagonist. Setipiprant interacts with hCRTH2 receptor with an IC50 value of 6 nM. Setipiprant inhibits prostanoid receptors hDP1 and hEP2 with IC50 values of 1290 and 2600 nM, respectively. Setipiprant can be used for the research of asthma and rhinitis.
    Setipiprant (Standard)
  • HY-B0131S
    Prostaglandin E1-d4
    		Agonist
    Prostaglandin E1-d4 is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases.
    Prostaglandin E1-d<sub>4</sub>
  • HY-114942
    Prostaglandin E1 ethyl ester
    		Control
    Prostaglandin E1 ethyl ester (Prostaglandin E1 Et ester) is the esterified form of Prostaglandin E1 (PGE1; HY-B0131). Prostaglandin E1 (Alprostadil) is a prostaglandin receptor ligand that induces vasodilation and inhibits platelet aggregation.
    Prostaglandin E1 ethyl ester
  • HY-176759
    AR-102 isopropyl ester
    		Agonist
    AR-102 isopropyl ester is a second-generation prostaglandin FP agonist. AR-102 isopropyl ester can be studied in research for glaucoma and ocular hypertension.
    AR-102 isopropyl ester
  • HY-106119
    Camonagrel
    		Inhibitor
    Camonagrel is a compound that has inhibitory effects on Prostaglandin E2. Camonagrel is a potent thromboxane synthase inhibitor.
    Camonagrel
  • HY-120752
    CAY10509
    		Inhibitor
    CAY10509 is a PGF2α analog and an inhibitor of the FP receptor with an IC50 of 30 nM. CAY10509 is promising for studying physiological regulatory mechanisms related to prostaglandins.
    CAY10509
  • HY-118332
    19(R)-HETE
    19(R)-HETE is a vasodilator in renal arteries, whereas 19(S)-HETE was relatively inactive.
    19(R)-HETE
  • HY-79593S3
    MRE-269-d7 sodium
    		Agonist
    MRE-269-d7 (ACT-333679-d7) sodium is deuterium-labeled MRE-269 (HY-79593).
    MRE-269-d<sub>7</sub> sodium
  • HY-79593S2
    MRE-269-d7
    		Agonist 99.59%
    MRE-269-d7 is deuterium labeled MRE-269 (HY-79593). MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.
    MRE-269-d<sub>7</sub>
  • HY-118670
    16(S)-Iloprost
    		Control
    16(S)-Iloprost is a stereoisomer of Iloprost. 16(S)-Iloprost inhibited platelet aggregation with IC50 value of 3.5 nM, and balanced binding with platelet membrane receptors Kd value of 13.4 nM.
    16(S)-Iloprost
  • HY-117862
    TASP0412098
    TASP0412098 is an orally available, potent and selective CRTH2/DP2 antagonist with high binding affinity (IC50 2.1 nM) and functional activity (IC50 12 nM). TASP0412098 has the potential to suppress asthma in mouse and guinea pig bronchial asthma models.
    TASP0412098
  • HY-79593R
    MRE-269 (Standard)
    		Agonist
    MRE-269 (Standard) is the analytical standard of MRE-269. This product is intended for research and analytical applications. MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.
    MRE-269 (Standard)
  • HY-10418R
    AH 6809 (Standard)
    		Antagonist
    AH 6809 (Standard) is the analytical standard of AH 6809. This product is intended for research and analytical applications. AH 6809 is an antagonist of EP and DP receptor, with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively. AH 6809 has a Ki of 350 nM for mouse EP2 receptor.
    AH 6809 (Standard)
  • HY-106699
    Taprostene sodium
    		Agonist
    Taprostene sodium is a partial agonist at prostanoid prostacyclin (IP) receptors. Taprostene sodium interacts additively with Prostaglandin E2 (PGE2) (HY-101952), ONO-AE1-259 (selective EP2 agonist), and acetylcholine. Taprostene sodium exerts a significant cardioprotection.
    Taprostene sodium
  • HY-126911
    11-keto Fluprostenol
    11-keto Fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.
    11-keto Fluprostenol
  • HY-119410
    Linotroban
    		Antagonist
    Linotroban (HN11500), a Sulotroban (HY-158332) derivative, is an orally active, potent non-prostanoid thromboxane receptor antagonist (TXRA) with a strong antiplatelet profile. Linotroban is used as antithrombotic agent.
    Linotroban
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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